Cancer Prevention and Control Program co-Leader
Shared Resource Director, Analytical Chemistry
Cancer Prevention and Control Program, Research Member
Biography
Dr. Chow is a Research Professor of Medicine at the University of Arizona Cancer Center (UACC). She has led the UACC Analytical Chemistry Shared Resource since 2001 and co-led the UACC Cancer Prevention and Control (CPC) Program since 2015. She has a long track record of leading early phase cancer prevention clinical trials, development and implementation of biochemical and molecular biomarkers for evaluation of cancer risk and drug efficacy, and pharmacokinetic/pharmacodynamics study design and data analysis.
Cancer Focus
Dr. Chow conducts clinical and translational research studies to identify potential targets for cancer prevention and to evaluate chemoprevention strategies. She has led a number of clinical trials to evaluate the potentials of different dietary compounds, repurposed drugs, and modified dosing schedules of established drugs for breast cancer prevention. In addition, she has led a NCI-funded Chemoprevention Consortium to conduct clinical investigations of various pharmaceutical and nutraceutical agents and vaccines for prevention of lung, breast, cervix, prostate, skin, esophageal, and head and neck cancer.
Selected Publications
Martinez, J. A., P. Chalasani, C. A. Thomson, D. Roe, M. Altbach, J-P. Galons, A. Stopeck, P. A. Thompson, D. Evelyn Villa-Guillen, and H-H. Sherry Chow, "Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol.", BMC Cancer, vol. 16, pp. 500, 2016 07 19. PMCID: PMC4950218 PMID: 27430256
López, A. María, S. Pruthi, J. C. Boughey, M. Perloff, C-H. Hsu, J. E. Lang, M. Ley, D. Frank, J. A. Taverna, and H-H. Sherry Chow, "Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk.", Cancer Prev Res (Phila), vol. 9, issue 2, pp. 142-8, 2016 Feb. PMCID: PMC4740217 PMID: 26667449
Miller, J. A., K. Pappan, P. A. Thompson, E. J. Want, A. P. Siskos, H. C. Keun, J. Wulff, C. Hu, J. E. Lang, and H-H. Sherry Chow, "Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.", Cancer Prev Res (Phila), vol. 8, issue 1, pp. 86-93, 2015 Jan. PMCID: PMC4289656 PMID: 25388013
Chow, H-H. Sherry, L. L. Garland, B. M. Heckman-Stoddard, C-H. Hsu, V. D. Butler, C. A. Cordova, W. M. Chew, and T. L. Cornelison, "A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones.", J Transl Med, vol. 12, pp. 223, 2014 Aug 14. PMCID: PMC4243716 PMID: 25115686
Miller, J. A., J. E. Lang, M. Ley, R. Nagle, C-H. Hsu, P. A. Thompson, C. Cordova, A. Waer, and H-H. Sherry Chow, "Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.", Cancer Prev Res (Phila), vol. 6, issue 6, pp. 577-84, 2013 Jun. PMCID: PMC3692564 PMID: 23554130