Education
Postdoctoral Research Fellowships:
Central Michigan University 2015
Indiana University School of Medicine 2011
Wayne State University 2010
PhD: Mysore University, 2008
Research Summary
Dr. Kamath's current research into mitochondrial DNA copy number (mtDNA) alterations in diseases spanning from pancreatic cancer to mental health disorders represents a multidisciplinary effort to unravel the molecular underpinnings of these conditions. By uncovering the role of mtDNA copy number changes, we aim to contribute to the development of novel diagnostic tools and therapeutic strategies and a deeper understanding of disease mechanisms in these diverse pathologies. Ultimately, this research promises to improve patient outcomes and quality of life across a spectrum of diseases.
Keyword: mitochondrial biogenesis, mitochondrial dysfunction, Prostate Cancer and Metabolic syndrome
Publications (Selected)
Ward AS, Hsiung CH, Kesterson DG, Kamath VG, McKee EE. Entecavir competitively inhibits deoxyguanosine and deoxyadenosine phosphorylation in isolated mitochondria and the perfused rat heart. J Biol Chem. 2022 Mar 28;298(5):101876.
Towheed A, Hietanen CL, Kamath VG, Singh LN, Ho A, Engelstad K, Cornett K, Montes J, De Vivo D. Hypotonia-cystinuria 2p21 deletion syndrome: Intrafamilial variability of clinical expression. Ann Clin Transl Neurol. 2021 Oct 6. doi: 10.1002/acn3.51464. Epub ahead of print. PMID: 34612606.
Snowdin JW, Hsiung CH, Kesterson DG, Kamath VG and McKee EE (2015) Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model. Antimicrob Agents Chemother. Oct;59(10):6328-36.
Vazquez EJ, Berthiaume JM, Kamath V, Achike O, Buchanan E, Montano MM, Chandler MP, Miyagi M, Rosca MG. (2015) Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. Cardiovasc Res. Sep 1;107(4):453-65.
Kamath VG, Hsiung C-H, Lizenby ZJ and McKee EE (2014) Heart Mitochondrial TTP Synthesis and the Compartmentalization of TMP. J Biol Chem Jan 23;290(4):2034-41.
Contact:
University of Arizona College of Medicine-Phoenix 425 North 5th Street, Phoenix, AZ 85004